In latent TB treatment with isoniazid, which supplement should be given?

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Multiple Choice

In latent TB treatment with isoniazid, which supplement should be given?

Explanation:
Isoniazid can cause peripheral neuropathy by depleting vitamin B6 (pyridoxine) in the body. Supplementing with pyridoxine provides the necessary cofactor to support nerve function and neurotransmitter synthesis, preventing this dose-related side effect. In practice, pyridoxine is given alongside isoniazid, commonly about 25–50 mg daily, with higher attention to those at higher risk for neuropathy (pregnant or lactating individuals, malnourished patients, diabetes, HIV, chronic alcohol use, elderly, kidney disease). The other substances listed are anti-TB drugs themselves and do not serve as the preventive vitamin supplement.

Isoniazid can cause peripheral neuropathy by depleting vitamin B6 (pyridoxine) in the body. Supplementing with pyridoxine provides the necessary cofactor to support nerve function and neurotransmitter synthesis, preventing this dose-related side effect. In practice, pyridoxine is given alongside isoniazid, commonly about 25–50 mg daily, with higher attention to those at higher risk for neuropathy (pregnant or lactating individuals, malnourished patients, diabetes, HIV, chronic alcohol use, elderly, kidney disease). The other substances listed are anti-TB drugs themselves and do not serve as the preventive vitamin supplement.

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