In suspected polyarteritis nodosa, which infection should be screened for?

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Prepare for the Rosh Internal Medicine Exam with quizzes, flashcards, and multiple-choice questions, complete with hints and explanations. Get ready to excel on your exam!

Multiple Choice

In suspected polyarteritis nodosa, which infection should be screened for?

Explanation:
Polyarteritis nodosa often occurs in the setting of hepatitis B infection. The disease is driven by immune complexes containing HBV antigens that deposit in medium-sized arteries, causing necrotizing vasculitis. Because HBV-associated PAN changes how you treat it—immunosuppression is used cautiously and antiviral therapy to control HBV is added—it's essential to screen for hepatitis B in suspected PAN. Infections like hepatitis A or E or acute cholecystitis are not the typical triggers or guiding factors for PAN management, so they’re not the priority screening targets in this scenario.

Polyarteritis nodosa often occurs in the setting of hepatitis B infection. The disease is driven by immune complexes containing HBV antigens that deposit in medium-sized arteries, causing necrotizing vasculitis. Because HBV-associated PAN changes how you treat it—immunosuppression is used cautiously and antiviral therapy to control HBV is added—it's essential to screen for hepatitis B in suspected PAN. Infections like hepatitis A or E or acute cholecystitis are not the typical triggers or guiding factors for PAN management, so they’re not the priority screening targets in this scenario.

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