Polymyositis is classically associated with which autoantibody?

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Prepare for the Rosh Internal Medicine Exam with quizzes, flashcards, and multiple-choice questions, complete with hints and explanations. Get ready to excel on your exam!

Multiple Choice

Polymyositis is classically associated with which autoantibody?

Explanation:
Polymyositis is an inflammatory myopathy often linked to antibodies against aminoacyl-tRNA synthetases, with anti-Jo-1 (anti-histidyl tRNA synthetase) being the most common. This antisynthetase antibody is classically associated with polymyositis and its related antisynthetase syndrome, which can include proximal muscle weakness plus features like interstitial lung disease, arthritis, mechanic’s hands, and Raynaud phenomenon. The other antibodies point to different diseases: anti-centromere is more associated with limited systemic sclerosis (CREST), while anti-dsDNA and anti-Smith are highly specific for systemic lupus erythematosus.

Polymyositis is an inflammatory myopathy often linked to antibodies against aminoacyl-tRNA synthetases, with anti-Jo-1 (anti-histidyl tRNA synthetase) being the most common. This antisynthetase antibody is classically associated with polymyositis and its related antisynthetase syndrome, which can include proximal muscle weakness plus features like interstitial lung disease, arthritis, mechanic’s hands, and Raynaud phenomenon. The other antibodies point to different diseases: anti-centromere is more associated with limited systemic sclerosis (CREST), while anti-dsDNA and anti-Smith are highly specific for systemic lupus erythematosus.

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