Polymyositis with Anti-Jo-1 antibodies is commonly associated with which extra-muscular manifestation?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Prepare for the Rosh Internal Medicine Exam with quizzes, flashcards, and multiple-choice questions, complete with hints and explanations. Get ready to excel on your exam!

Multiple Choice

Polymyositis with Anti-Jo-1 antibodies is commonly associated with which extra-muscular manifestation?

Explanation:
Anti-Jo-1 antibodies define the anti-synthetase syndrome, a subset of inflammatory myopathies where muscle inflammation is accompanied by other organ involvement, most commonly the lungs. Interstitial lung disease arising in this context causes dyspnea and cough and shows restrictive physiology on testing with characteristic patterns on imaging. Because of this strong association, interstitial lung disease is the classic extra-muscular manifestation linked to anti-Jo-1. Hypercalcemia, acute pancreatitis, and pulmonary embolism are not typical features of this antibody syndrome.

Anti-Jo-1 antibodies define the anti-synthetase syndrome, a subset of inflammatory myopathies where muscle inflammation is accompanied by other organ involvement, most commonly the lungs. Interstitial lung disease arising in this context causes dyspnea and cough and shows restrictive physiology on testing with characteristic patterns on imaging. Because of this strong association, interstitial lung disease is the classic extra-muscular manifestation linked to anti-Jo-1.

Hypercalcemia, acute pancreatitis, and pulmonary embolism are not typical features of this antibody syndrome.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy